Fascaplysin, ATP-competitve CDK4 inhibitor (ab146177)
Key features and details
- Potent, selective ATP-competitve CDK4 inhibitor
- CAS Number: 114719-57-2
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Fascaplysin, ATP-competitve CDK4 inhibitor -
Description
Potent, selective ATP-competitve CDK4 inhibitor -
Biological description
Potent, selective ATP-competitive CDK4 inhibitor (IC50 = 350 nM). Suppresses VEGF expression and inhibits endothelial cell proliferation. Induces apoptosis and cytotoxic autophagy in vitro. -
CAS Number
114719-57-2 -
Chemical structure
Properties
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Molecular weight
306.75 -
Molecular formula
C18H11ClN2O -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
[Cl-].O=C4c1ccccc1[n+]5ccc2c(nc3ccccc23)c45 -
Source
Synthetic
