Everolimus, mTOR inhibitor (ab142151)
Key features and details
- Potent mTOR inhibitor
- CAS Number: 159351-69-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Everolimus, mTOR inhibitor -
Description
Potent mTOR inhibitor -
Biological description
Potent mTOR inhibitor (IC50 = 1.6 - 2.4 nM). Immunosupressant and anticancer activity in vivo. Orally active. -
Purity
> 98% -
CAS Number
159351-69-6 -
Chemical structure
Properties
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Chemical name
Dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone -
Molecular weight
958.22 -
Molecular formula
C53H83NO14 -
PubChem identifier
6442177 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC -
Source
Synthetic
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Research areas
