Erucin, Isothiocyanate (ab141931)
Key features and details
- Isothiocyanate. Apoptosis inducer.
- CAS Number: 4430-36-8
- Purity: > 98%
- Soluble in DMSO to 75 mM and in ethanol to 75 mM
- Form / State: Solid
- Source: Brassica sp.
Overview
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Product name
Erucin, Isothiocyanate -
Description
Isothiocyanate. Apoptosis inducer. -
Biological description
Isothiocyanate. Induces apoptosis and shows anti-proliferative activity against some cancer cell types. -
Purity
> 98% -
CAS Number
4430-36-8 -
Chemical structure
Properties
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Chemical name
1-Isothiocyanato-4-methylsulfanylbutane -
Molecular weight
161.29 -
Molecular formula
C6H11NS2 -
PubChem identifier
78160 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in ethanol to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CSCCCCN=C=S -
Source
Brassica sp.
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Research areas
Images
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Functional Studies - Erucin, Isothiocyanate (ab141931)ab26 staining p53 in A549 cells treated with erucin (ab141931), by ICC/IF. Increase in p53 expression correlates with increased concentration of erucin, as described in literature.
The cells were incubated at 37°C for 1 hour in media containing different concentrations of ab141931 (erucin) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab26 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
