Eplerenone, Selective mineralocorticoid antagonist (ab141251)
Key features and details
- Selective mineralocorticoid antagonist
- CAS Number: 107724-20-9
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Eplerenone, Selective mineralocorticoid antagonist -
Description
Selective mineralocorticoid antagonist -
Biological description
Selective mineralocorticoid (aldosterone) antagonist (IC50 = 81 nM). Significantly greater selectivity than spironolactone at androgen, progesterone and glucocorticoid receptors. Antihypertensive, orally active in vivo.
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Purity
> 99% -
CAS Number
107724-20-9 -
Chemical structure
Properties
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Chemical name
(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic acid γ-lactone 7-methyl ester -
Molecular weight
414.50 -
Molecular formula
C24H30O6 -
PubChem identifier
443872 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(OC)[C@@H]4CC1=CC(=O)CC[C@]1(C)[C@@]65O[C@@H]6C[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45 -
Source
Synthetic
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Research areas