Epirubicin hydrochloride (Ellence), Topoisomerase II inhibitor (ab142100)
Key features and details
- Topoisomerase II inhibitor. Cell-permeable.
- CAS Number: 56390-09-1
- Purity: > 95%
- Soluble in water to 100 mM (with warming) and in DMSO to 100 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Epirubicin hydrochloride (Ellence), Topoisomerase II inhibitor -
Description
Topoisomerase II inhibitor. Cell-permeable. -
Biological description
Topoisomerase II inhibitor (IC50 = 12 μM). Steroisomer of Doxorubicin (Asc 629). Shows antitumor and antiangiogenic activity in vivo. Cell-permeable. -
Purity
> 95% -
CAS Number
56390-09-1 -
Chemical structure
Properties
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Chemical name
(8S,10S)-10-((3-amino-2,3,6-trideoxy-β-L-arabinohexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione hydrochloride -
Molecular weight
579.98 -
Molecular formula
C27H29NO11.HCl -
PubChem identifier
65348 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM (with warming) and in DMSO to 100 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C(C(CC(O1)OC2CC(CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl -
Source
Synthetic
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Research areas
