Embelin, cell-permeable inhibitor of X-linked inhibitor of apoptosis (ab141061)
Key features and details
- Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis
- CAS Number: 550-24-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Embelin, cell-permeable inhibitor of X-linked inhibitor of apoptosis -
Description
Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis -
Biological description
Potent, cell-permeable inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM). Binds to the XIAP BIR3 protein and interacts with residues crucial for Smac and caspsase-9 binding. Inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells (IC50 = 3.7 - 5.7 μM); minimal effects on normal prostate cells (IC50 = 19.3 - 20.1 μM). Antitumor and anti-inflammatory effects in vivo.
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Purity
> 98% -
CAS Number
550-24-3 -
Chemical structure
