Elvitegravir, quinolone HIV integrase inhibitor (ab231510)
Key features and details
- Potent quinolone HIV integrase inhibitor
- CAS Number: 697761-98-1
- Purity: > 99%
Soluble in DMSO and dimethyl formamide to 10mg/ml and 20mg/ml respectively.
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Elvitegravir, quinolone HIV integrase inhibitor -
Description
Potent quinolone HIV integrase inhibitor -
Biological description
Elvitegravir is an inhibitor of HIV integrase. It inhibits HIV integrase from HIV 1 IIIB (IC50 = 0.7 nM), HIV 2 EHO (IC50 = 2.8 nM) and HIV-2 ROD (IC50 = 1.1 nM) in cell free assays. Elvitegravir blocks integration of HIV cDNA via inhibition of DNA strand transfer. Active against a range of HIV sub-types and against mulit-drug resistant clinical isolates. Potent (IC50 range = 0.21 - 1.15 nM) HIV antiviral activity in various cell-based assays.
-
Purity
> 99% -
CAS Number
697761-98-1 -
Chemical structure
Properties
-
Chemical name
6-[(3-Chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxoquinoline-3-carboxylic acid
-
Molecular weight
447.89 -
Molecular formula
C23H23ClFNO5 -
PubChem identifier
5277135 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
Soluble in DMSO and dimethyl formamide to 10mg/ml and 20mg/ml respectively.
-
SMILES
CC(C)[C@@H](CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O -
Source
Synthetic
