Doxepin hydrochloride, monoamine receptor antagonist (ab143312)
Key features and details
- Potent monoamine receptor antagonist and reuptake inhibitor
- CAS Number: 1229-29-4
- Purity: > 98%
- Soluble in 1 N HCl to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Doxepin hydrochloride, monoamine receptor antagonist -
Description
Potent monoamine receptor antagonist and reuptake inhibitor -
Biological description
Potent monoamine receptor antagonist and reuptake inhibitor (Ki values are 276, 26, 9, 136, 24, 1270, 38, 160, 52, 82, 75, 360, 0.2, 106, 68 and 30 nM for 5-HT1A, 5-HT2A, 5HT2C, 5-HT6, α1, α2, M1, M2, M3, M4, , D2, H1, H4, SERT and NET respectively). Shows antidepressant, anxiolytic, sedative and antipruritic effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
1229-29-4 -
Chemical structure
Properties
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Chemical name
(3E)-3-(6H-Benzo[c][1]benzoxepin-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride salt -
Molecular weight
315.84 -
Molecular formula
C19H21NO.HCl -
PubChem identifier
6419921 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in 1 N HCl to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CCC=C1C2=CC=CC=C2COC3=CC=CC=C31.Cl -
Source
Synthetic
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Research areas
