Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843)
Key features and details
- Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
- CAS Number: 866405-64-3
- Purity: > 99%
- Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dorsomorphin (Compound C), AMP-kinase inhibitor -
Description
Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling. -
Alternative names
- Compound C
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Biological description
Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821) -
Purity
> 99% -
CAS Number
866405-64-3 -
Chemical structure
Properties
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Chemical name
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine -
Molecular weight
399.49 -
Molecular formula
C24H25N5O -
PubChem identifier
11524144 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM (with heating) and to ethanol to 5 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Please note that sonication in a 55 °C water bath is necessary for dissolution of ab120843 in DMSO to 10 mM.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5 -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
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Functional Studies - Dorsomorphin (Compound C), AMP-kinase inhibitor (ab120843) Li et al PLoS One. 2015 Sep 23;10(9):e0138390. doi: 10.1371/journal.pone.0138390. eCollection 2015. Fig 6. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
G9a inhibition induces autophagy and autophagic cell death through AMPK/mTOR pathway.
T24 cells (Panel G) and UMUC-3 cells (Panel H) were pre-treated with compound C (5 μM) or AICAR (1 mM) and then treated with BIX-01294 (1.5 μM) for 48 h, Cells viability was assessed by MTT assay. *P
