DMAPT, NF-kappaB inhibitor (ab146189)
Key features and details
- NF-κB inhibitor
- CAS Number: 870677-05-7
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DMAPT, NF-kappaB inhibitor -
Description
NF-κB inhibitor -
Alternative names
- Dimethylaminoparthenolide
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Biological description
NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active. -
CAS Number
870677-05-7 -
Chemical structure
Properties
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Chemical name
(1aR,4E,7aS,8R,10aS,10bS)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
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Molecular weight
293.41 -
Molecular formula
C17H27NO3 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
