Dinaciclib, cyclin-dependent kinase (CDK) inhibitor (ab219469)
Key features and details
- Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor
- CAS Number: 779353-01-4
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dinaciclib, cyclin-dependent kinase (CDK) inhibitor -
Description
Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor -
Alternative names
- MK-7965
- SCH 727965
- SCH727965
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Biological description
Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC50 values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC50 = 4 nM).
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Purity
> 98% -
CAS Number
779353-01-4 -
Chemical structure
Properties
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Chemical name
2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol -
Molecular weight
396.49 -
Molecular formula
C21H28N6O2 -
PubChem identifier
46926350 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO -
Source
Synthetic
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Research areas
