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Cancer Tumor immunology Cytokines Interleukins

Diacerein, Interleukin-1B (IL-1B) production inhibitor (ab142284)

Key features and details

  • Inhibitor of interleukin-1B (IL-1B) production
  • CAS Number: 13739-02-1
  • Purity: > 96%
  • Soluble in DMSO to 25 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Diacerein, Interleukin-1B (IL-1B) production inhibitor
  • Description

    Inhibitor of interleukin-1B (IL-1B) production
  • Biological description

    Inhibitor of interleukin-1B (IL-1B) production. Prevents cartilage breakdown in osteoarthritis models. Diacerein metabolite (rhein) reduces superoxide anion production in human neutrophils. Anti-inflammatory. Active in vivo.
  • Purity

    > 96%
  • CAS Number

    13739-02-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4,5-Diacetyloxy-9,10-dioxoanthracene-2-carboxylic acid
  • Molecular weight

    368.29
  • Molecular formula

    C19H12O8
  • PubChem identifier

    26248
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)OC1=CC=CC2=C1C(=O)C3=C(C=C(C=C3C2=O)C(=O)O)OC(=O)C
  • Source

    Synthetic

  • Research areas

    • Immunology
    • Innate Immunity
    • Cytokines
    • Interleukins
    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Biochemicals
    • Pharmacology
    • Signaling
    • Signal transduction
    • Cytokines, NF-κB & IκB signaling
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Enzyme-Linked Receptors
    • Cytokine receptors
    • Other
    • Biochemicals
    • Pharmacology
    • Signaling
    • Immunomodulators
    • Immunomodulators & Immunosuppressants

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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