Cytostatin, PP2A inhibitor (ab144235)
Key features and details
- Potent, selective PP2A inhibitor. Cell adhesion inhibitor.
- CAS Number: 156856-30-3
- Purity: > 75%
- Soluble in water and in DMSO
- Form / State: Solid
- Source: Streptomyces sp.
Overview
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Product name
Cytostatin, PP2A inhibitor -
Description
Potent, selective PP2A inhibitor. Cell adhesion inhibitor. -
Biological description
Potent, selective protein phosphatase 2A (PP2A) inhibitor. Cell adhesion inhibitor. Inhibits the adhesion of B16 melanoma cells to laminin and collagen type IV in a dose dependent manner but not to fibronectin. Antitumor agent. Antimetastatic. Apoptosis inducer. -
Purity
> 75% -
CAS Number
156856-30-3 -
Chemical structure
Properties
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Chemical name
(2S,5S,6S,7S,8Z,10Z,12E)-7-Hydroxy-6-methyl-2-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)tetradeca-8,10,12-trien-5-yl hydrogen phosphate sodium -
Molecular weight
450.44 -
Molecular formula
C21H32NaO7P -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water and in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C\C=C\C=C/C=C\C(O)C(C)C(CCC(C)C1OC(=O)C=CC1C)OP(=O)(O)O[Na] -
Source
Streptomyces sp.
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Research areas
