Cyclopamine, Hh signaling inhibitor (ab120392)
Key features and details
- Hh signaling inhibitor
- CAS Number: 4449-51-8
- Purity: > 98%
- Soluble in ethanol to 5 mM
- Form / State: Solid
- Source: Veratrum californicum
Overview
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Product name
Cyclopamine, Hh signaling inhibitor -
Description
Hh signaling inhibitor -
Biological description
Cell-permeable inhibitor of hedgehog (Hh) signaling, via direct inhibition of Smo (Smoothened), the accessory protein to the putative Hh receptor. Anticancer and teratogenic activity in vivo.
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Purity
> 98% -
CAS Number
4449-51-8 -
Chemical structure
Properties
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Chemical name
(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a, 4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol -
Molecular weight
411.63 -
Molecular formula
C27H41NO2 -
PubChem identifier
442972 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC4=C5C[C@@H]1[C@@]6(C)CC[C@H](O)CC6=CC[C@H]1[C@@H]5CC[C@@]24O[C@@H]3C[C@H](C)CN[C@H]3[C@H]2C -
Source
Veratrum californicum
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Research areas