Cyclopamine (ethanol solution), Hh signaling inhibitor (ab146596)
Key features and details
- Hh signaling inhibitor
- CAS Number: 4449-51-8
- Purity: > 99%
- Supplied in ethanol (10 mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Cyclopamine (ethanol solution), Hh signaling inhibitor -
Description
Hh signaling inhibitor -
Biological description
Cell-permeable inhibitor of hedgehog (Hh) signaling, via direct inhibition of Smo (Smoothened), the accessory protein to the putative Hh receptor. Anticancer and teratogenic activity in vivo.
Also available as a solid (ab120392). -
Purity
> 99% -
CAS Number
4449-51-8 -
Chemical structure
Properties
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Chemical name
(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6,10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol -
Molecular weight
411.63 -
Molecular formula
C27H41NO2 -
PubChem identifier
442972 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in ethanol (10 mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC4=C5C[C@@H]1[C@@]6(C)CC[C@H](O)CC6=CC[C@H]1[C@@H]5CC[C@@]24O[C@@H]3C[C@H](C)CN[C@H]3[C@H]2C -
Source
Synthetic
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Research areas
