Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor (ab146030)
Key features and details
- Cell-permeable transcriptional p53 inhibitor
- CAS Number: 60477-38-5
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor -
Description
Cell-permeable transcriptional p53 inhibitor -
Biological description
Cell-permeable transcriptional p53 inhibitor. Shows potent neuroprotective effects (ED50 = 30 nM, etoposide-induced cortical neuron death). Shows a 50% longer half-life than Pifithrin-α (ab120478).
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Purity
> 99% -
CAS Number
60477-38-5 -
Chemical structure
Properties
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Chemical name
5,6,7,8-Tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole -
Molecular weight
299.35 -
Molecular formula
C15H13N3O2S -
PubChem identifier
4587369 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-] -
Source
Synthetic
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Research areas
