Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618)
Key features and details
- Flavonoid. Lipooxygenase inhibitor. Antioxidant, anti-inflammatory agent.
- CAS Number: 458-37-7
- Soluble in ethanol to 10 mM and in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Curcumin (Diferuloylmethane), Lipooxygenase inhibitor -
Description
Flavonoid. Lipooxygenase inhibitor. Antioxidant, anti-inflammatory agent. -
Alternative names
- Diferuloylmethane
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Biological description
Flavonoid derived from Curcuma longa plant. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Blood-brain barrier permeable. Shows diverse range of actions including free radical scavenging activity in vitro and in vivo, cardio and neuroprotective effects.
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CAS Number
458-37-7 -
Chemical structure
Images
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Functional Studies - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618)ab32137 staining c-Jun in HeLa cells treated with curcumin (diferuloylmethane) (ab120618), by ICC/IF. Decrease in c-Jun expression correlates with increased concentration of curcumin (diferuloylmethane) as described in literature.
The cells were incubated at 37°C for 4h in media containing different concentrations of ab120618 (curcumin (diferuloylmethane)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32137 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
