CUR 61414, Hedgehog signaling pathway antagonist (ab222964)
Key features and details
- Novel, cell permeable Hedgehog signaling pathway antagonist
- CAS Number: 334998-36-6
- Purity: > 98%
- Soluble in DMSO to 70 mM and in ethanol to 30 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CUR 61414, Hedgehog signaling pathway antagonist -
Description
Novel, cell permeable Hedgehog signaling pathway antagonist -
Alternative names
- CUR61414
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Biological description
Novel, cell permeable Hedgehog signaling pathway antagonist (IC50 = 100-200 nM). Selectively binds to smoothened (Smo) (Ki = 44 nM). Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
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Purity
> 98% -
CAS Number
334998-36-6
Properties
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Chemical name
N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide -
Molecular weight
550.71 -
Molecular formula
C31H42N4O5 -
PubChem identifier
10392802 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 70 mM and in ethanol to 30 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)[C@H]2C[C@H](N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5 -
Source
Synthetic
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Research areas
