CP690550 (Tofacitinib) citrate (ab254232)
Key features and details
Cell-permeable JAK1/2/3 inhibitor
- CAS Number: 540737-29-9
- Purity: > 99%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CP690550 (Tofacitinib) citrate -
Description
Cell-permeable JAK1/2/3 inhibitor
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Alternative names
- Tasocitinib citrate salt
- Tofacitinib Citrate
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Biological description
Potent, cell-permeable inhibitor of JAK1/2/3 (in cell-free assays JAK1 IC50 = 112 nM; JAK2 IC50 = 20 nM; JAK3 IC50 = 1 nM). Exhibits immunosuppressive, anti-inflammatory, and antiviral activities. Inhibits production of inflammatory cytokines, Th2 cell differentiation, Th17 cell differentiation, and activation of STAT1 in vitro. Prevents induction of T-bet and generation of Th1 cells. Inhibits HIV replication and reactivation of latent HIV-1 in cell models.
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Purity
> 99% -
CAS Number
540737-29-9 -
Chemical structure
Properties
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Chemical name
3-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylic acid
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Molecular weight
504.50 -
Molecular formula
C22H28N6O8 -
PubChem identifier
10174505 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O -
Source
Synthetic
