Chk2 inhibitor II, ATP-competitive checkpoint kinase (Chhk) 2 inhibitor (ab142086)
Key features and details
- Potent, ATP-competitive checkpoint kinase (Chhk) 2 inhibitor. Cell-permeable.
- CAS Number: 516480-79-8
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Chk2 inhibitor II, ATP-competitive checkpoint kinase (Chhk) 2 inhibitor -
Description
Potent, ATP-competitive checkpoint kinase (Chhk) 2 inhibitor. Cell-permeable. -
Biological description
Potent, ATP-competitive checkpoint kinase 2 inhibitor (IC50 = 15 nM; Ki = 37 nM). Controls p53 response to DNA breaks. leading to apoptosis. Cell-permeable. -
Purity
> 98% -
CAS Number
516480-79-8 -
Chemical structure
Properties
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Chemical name
2-[4-(4-Chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide -
Molecular weight
363.80 -
Molecular formula
C20H14CIN3O2 -
PubChem identifier
9969021 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl -
Source
Synthetic
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Research areas