Ceefourin™ 2, MRP4 inhibitor (ab145145)
Key features and details
- Highly selective multidrug resistance protein 4 (MRP4) inhibitor
- CAS Number: 348148-51-6
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Ceefourin™ 2, MRP4 inhibitor -
Description
Highly selective multidrug resistance protein 4 (MRP4) inhibitor -
Biological description
Highly selective multidrug resistance protein 4 (MRP4) inhibitor (IC50 = 7 µM). Blocked transport of MRP4 substrates, including 6-Mercaptopurine, SN 38, D-Luciferin and E217βG. No detectable effect on MRP4 homologs MRP1, 2, 3 or 5, and related transporters P-gp and ABCG2 in vitro. Low cellular toxicity, and high microsomal and acid stability. Chemically distinctive to Ceefourin™ 1 (ab145144).
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Purity
> 98% -
General notes
Sold under exclusive licence from Children's Cancer Institute. Ceefourin™ is a trademark of Children's Cancer Institute. -
CAS Number
348148-51-6 -
Chemical structure
Properties
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Chemical name
3-Chloro-5-(4-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid -
Molecular weight
355.70 -
Molecular formula
C15H9ClF3N3O2 -
PubChem identifier
1366977 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)O)c3ccc(C)cc3 -
Source
Synthetic
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Research areas
