Cabergoline, D2-like receptor agonist (ab120564)
Key features and details
- D2-like receptor agonist
- CAS Number: 81409-90-7
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cabergoline, D2-like receptor agonist -
Description
D2-like receptor agonist -
Biological description
D2-like receptor agonist (Ki values are 0.7 (D2), 1.5 (D3), 9.0 (D4) and 165 nM (D5)). Highly potent at some 5-HT receptors (Ki values are 20 (5-HT1A), 8.7 (5-HT1D), 6.2 (5-HT2A) and 1.2 nM (5-HT2B)). Shows antitumour effects and has antidepressant and anxiolytic properties.
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Purity
> 99% -
CAS Number
81409-90-7 -
Chemical structure
Properties
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Chemical name
N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8ß-carboxamide -
Molecular weight
451.60 -
Molecular formula
C26H37N5O2 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Functional Studies - Cabergoline, D2-like receptor agonist (ab120564)
PC12 cells were incubated at 37ºC for 30 minutes with vehicle control (0 µM) and different concentrations of cabergoline (ab120564). Increased expression of AKT1 (phospho S473) (ab66138) in PC12 cells correlates with an increase in cabergoline concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 µg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with ab66138 at 1/1000 dilution and ab8227 at 1 µg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (ab97051) at 1/10000 dilution and visualised using ECL development solution.
