BQ-123, ETA receptor antagonist (ab141005)
Key features and details
- Potent, selective ETA receptor antagonist
- CAS Number: 136553-81-6
- Purity: > 95%
- Soluble in water to 1.25 mg/ml
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BQ-123, ETA receptor antagonist -
Description
Potent, selective ETA receptor antagonist -
Biological description
Potent, selective ETA receptor antagonist (IC50 values are 7.3 and 18,000 nM for ETA and ETB endothelin receptors respectively). Some ability to cross the blood-brain barrier. Anti-ischemic activity in vivo.
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Purity
> 95% -
CAS Number
136553-81-6 -
Chemical structure
Properties
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Molecular weight
610.70 -
Molecular formula
C31H42N6O7 -
Sequence
WDPVL (Modifications: Trp-1 = D-Trp; Asp-2 = D-Asp; Val-4 = D-Val; Cyclised: 1-5) -
PubChem identifier
443289 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 1.25 mg/ml -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43 -
Source
Synthetic
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Research areas
