Bortezomib, proteasome inhibitor (ab142123)
Key features and details
- Potent, selective, reversible proteasome inhibitor
- CAS Number: 179324-69-7
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 90 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bortezomib, proteasome inhibitor -
Description
Potent, selective, reversible proteasome inhibitor -
Alternative names
- MG-341
- PS-341
- Velcade
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Biological description
Potent, selective, reversible proteasome inhibitor (Ki = 0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50 = 7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis.
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Purity
> 98% -
CAS Number
179324-69-7 -
Chemical structure
Properties
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Chemical name
N-(2-Pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid -
Molecular weight
384.25 -
Molecular formula
C19H25BN4O4 -
PubChem identifier
387447 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 90 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O -
Source
Synthetic
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Research areas
