BIIB 021 (ab273599)
Key features and details
- Selective, competitive HSP90 inhibitor.
- CAS Number: 848695-25-0
- Purity: > 98%
Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
BIIB 021 -
Description
Selective, competitive HSP90 inhibitor. -
Biological description
Selective, Hsp90 competitive inhibitor (Ki = 1.7 nM). Displays no significant activity at a range of ATP-binding kinases or Na+K+ ATPase. Induces degradation of HER-2 in vitro (EC50 = 38 nM in MCF-7 cells). Inhibits growth and promotes cell death in a variety of human tumor cells. Orally bioavailable.
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Purity
> 98% -
CAS Number
848695-25-0 -
Chemical structure
Properties
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Chemical name
6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
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Molecular weight
318.80 -
Molecular formula
C14H15ClN6O -
PubChem identifier
16736529 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 100 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CN=C(C(=C1OC)C)CN2C=NC3=C2N=C(N=C3Cl)N -
Source
Synthetic
Images
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Chemical Structure - BIIB 021 (ab273599)
Chemical structure of BIIB 021, 848695-25-0
