beta-Secretase Inhibitor II (Z-VLL-CHO), beta-secretase inhibitor (ab146640)
Key features and details
- Cell-permeable, reversible β-secretase inhibitor
- CAS Number: 263563-09-3
- Purity: > 95%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
beta-Secretase Inhibitor II (Z-VLL-CHO), beta-secretase inhibitor -
Description
Cell-permeable, reversible β-secretase inhibitor -
Alternative names
- Z-VLL-CHO
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Biological description
Cell-permeable, reversible β-secretase inhibitor. Corresponds to the VNL-DA cleavage site on APP. Inhibits Aβ formation (IC50 values are 0.7 and 2.5 µM for Aβtotal and Aβ1-42 respectively). Shows neuroprotective effects. -
Purity
> 95% -
CAS Number
263563-09-3 -
Chemical structure
Properties
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Chemical name
benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]carbamate
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Molecular weight
461.60 -
Molecular formula
C25H39N3O5 -
Sequence
VVL (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde) -
PubChem identifier
10253763 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1 -
Source
Synthetic
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Research areas