Berbamine dihydrochloride, NF-kappaB inhibitor (ab145637)
Key features and details
- NF-κB inhibitor. Potent antitumor agent.
- CAS Number: 6078-17-7
- Purity: > 98%
- Soluble in ethanol and in DMSO to 100 mM
- Form / State: Solid
- Source: Berberis amurensis
Overview
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Product name
Berbamine dihydrochloride, NF-kappaB inhibitor -
Description
NF-κB inhibitor. Potent antitumor agent. -
Biological description
NF-κB inhibitor. Potent antitumor agent. Inhibits Bcr-Abl signaling in blood cancers. Shows antiproliferative effects, induces G1 phase arrest and apoptosis. Downregulates IKKα and p-IκBα expression. Increases A20 expression. Inhibits p65 nuclear localization. -
Purity
> 98% -
CAS Number
6078-17-7 -
Chemical structure
Properties
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Chemical name
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol dihydrochloride -
Molecular weight
681.65 -
Molecular formula
C37H40N2O6.2HCl -
PubChem identifier
16217067 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(O3)C(=C(C=C7CCN6C)OC)OC)O)OC.Cl.Cl -
Source
Berberis amurensis
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Research areas