Baicalein, Lipoxygenase inhibitor. (ab120723)
Key features and details
- Flavonoid. Lipoxygenase inhibitor.
- CAS Number: 491-67-8
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Baicalein, Lipoxygenase inhibitor. -
Description
Flavonoid. Lipoxygenase inhibitor. -
Biological description
Cell-permeable flavonoid. Lipoxygenase inhibitor (IC50 values are 0.64 and 1.6 μM at 12- and 15-lipoxygenases, respectively). Shows antioxidant and anti-inflammatory properties. Also induces apoptosis. Additionally, inhibits α-syn oligomerisation, β-Amyloid induced neurotoxicity and amyloid protein aggregation.
-
Purity
> 98% -
CAS Number
491-67-8 -
Chemical structure
Properties
-
Chemical name
5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one -
Molecular weight
270.24 -
Molecular formula
C15H10O5 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
Source
Synthetic
-
Research areas
Images
-
Functional Studies - Baicalein, Lipoxygenase inhibitor. (ab120723)ab51608 staining HIF1α in HepG2 cells treated with baicalein (ab120723), by ICC/IF. Increase in HIF1α expression correlates with increased concentration of baicalein as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120723 (baicalein) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab51608 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.