Bafetinib (INNO-406) (ab273520)
Key features and details
- Potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase
- CAS Number: 859212-16-1
- Purity: > 99%
≥57.7mg/mL in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Bafetinib (INNO-406) -
Description
Potent and selective dual inhibitor of Bcr-Abl/Lyn tyrosine kinase -
Alternative names
- INNO-406
- NS-187
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Biological description
Potent and selective orally bioavailable dual inhibitor of Bcr-Abl/Lyn tyrosine kinase with IC50 values of 5.8nM and 19nM, respectively. Can block the autophosphorylation of Bcr-Abl. Highly potent to inhibit tumor growth in murine tumor models.
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Purity
> 99% -
CAS Number
859212-16-1 -
Chemical structure
Properties
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Chemical name
N-[3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3- (dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide
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Molecular weight
576.62 -
Molecular formula
C30H31F3N8O -
PubChem identifier
11387605 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
≥57.7mg/mL in DMSO
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC(=C(C=C2)CN3CC[C@@H](C3)N(C)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CN=C5 -
Source
Synthetic
Images
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Chemical Structure - Bafetinib (INNO-406) (ab273520)
Chemical structure of Bafetinib (INNO-406), 859212-16-1