AZ-20 (ab273623)
Key features and details
- Potent and selective ATR inhibitor
- CAS Number: 1233339-22-4
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AZ-20 -
Description
Potent and selective ATR inhibitor -
Biological description
Potent and selective ATR kinase inhibitor (IC50 = 5 nM in vitro; IC50 = 50 nM in carcinoma cell lines). Selective versus mTOR (8-fold). Displayed selectivity versus a panel of 442 kinases.Inhibits LoVo colorectal adenocarcinoma tumor cell growth.
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Purity
98% -
CAS Number
1233339-22-4 -
Chemical structure
Properties
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Chemical name
4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole
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Molecular weight
412.51 -
Molecular formula
C21H24N4O3S -
PubChem identifier
46244454 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 25 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=O)(=O)C)C4=C5C=CNC5=CC=C4 -
Source
Synthetic
Images
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Chemical Structure - AZ-20 (ab273623)
Chemical structure of AZ-20, 1233339-22-4