Atorvastatin, HMG-CoA reductase inhibitor (ab145604)
Key features and details
- Potent, selective and competitve HMG-CoA reductase inhibitor
- CAS Number: 134523-00-5
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Atorvastatin, HMG-CoA reductase inhibitor -
Description
Potent, selective and competitve HMG-CoA reductase inhibitor -
Biological description
Potent, selective and competitive HMG-CoA reductase inhibitor (IC50 = 154 nM). Lowers serum total and LDL cholesterol, apoB, and triglyceride levels while increasing HDL cholesterol. Reduces cholesterol synthesis in vivo. Orally active. -
Purity
> 98% -
CAS Number
134523-00-5 -
Chemical structure
Properties
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Chemical name
(3R,5R)-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid -
Molecular weight
558.64 -
Molecular formula
C33H35FN2O5 -
PubChem identifier
60823 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4 -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
