AR-A014418, GSK-3 inhibitor (ab141295)
Key features and details
- Highly selective GSK-3 inhibitor
- CAS Number: 487021-52-3
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AR-A014418, GSK-3 inhibitor -
Description
Highly selective GSK-3 inhibitor -
Biological description
Highly selective GSK-3 inhibitor (IC50 = 104 nM). ATP competitive (Ki = 38 nM). Selective over cdc2, cdc5 and 26 other kinases. Inhibits tau phosphorylation (ser 396) at a GSK-3 specific site. Blood-brain barrier permeable.
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Purity
> 99% -
CAS Number
487021-52-3 -
Chemical structure
Properties
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Chemical name
N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea -
Molecular weight
308.31 -
Molecular formula
C12H12N4O4S -
PubChem identifier
448014 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(Nc1ncc(s1)[N+]([O-])=O)NCc2ccc(OC)cc2 -
Source
Synthetic
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Research areas
