Anti-Reticulon 1A antibody [MON160] (ab8957)
![Anti-Reticulon 1A antibody [MON160] (ab8957)](https://www.abcam.com/ps/products/8/ab8957/Images/ab8957_1.gif "Anti-Reticulon 1A antibody [MON160] (ab8957)")
Key features and details
- Mouse monoclonal [MON160] to Reticulon 1A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-Reticulon 1A antibody [MON160]
See all Reticulon 1A primary antibodies -
Description
Mouse monoclonal [MON160] to Reticulon 1A -
Host species
Mouse -
Specificity
This antibody exclusively recognizes the 135 kDa Reticulon-1A protein in immunoblots of NCI-H82 and other SCLC cell lines, and stains normal and pathological neural and neuroendocrine tissues -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Fusion protein corresponding to Reticulon 1A aa 6-776. Partially purified bacterially expressed Reticulon-1A (NSP-A) hybrid protein (beta-GAL-NSP-A 6-776).
Database link: Q16799 -
Epitope
This antibody is reactive with residues 174-337 of Reticulon-1A. -
General notes
A central structure in the secretory pathway of the cell comprises an elaborate endomembranous system with the multifunctional endoplasmic reticulum (ER) as a major constituent. Newly synthesized secretory proteins and a variety of resident proteins of the pathway enter the rough endoplasmic reticulum. Subsequently, the proteins may be sorted selectively to different membrane-delimited organelles including the Golgi apparatus, endosomes, lysosomes and secretory vesicles. Abcam provides antibodies to a new family of ER-associated proteins, the reticulons, which show a tissue specific distribution.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Primary antibody notes
A central structure in the secretory pathway of the cell comprises an elaborate endomembranous system with the multifunctional endoplasmic reticulum (ER) as a major constituent. Newly synthesized secretory proteins and a variety of resident proteins of the pathway enter the rough endoplasmic reticulum. Subsequently, the proteins may be sorted selectively to different membrane-delimited organelles including the Golgi apparatus, endosomes, lysosomes and secretory vesicles. Abcam provides antibodies to a new family of ER-associated proteins, the reticulons, which show a tissue specific distribution. -
Clonality
Monoclonal -
Clone number
MON160 -
Myeloma
unknown -
Isotype
IgG1 -
Research areas
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulon 1A antibody [MON160] (ab8957)
NSP-A immunostaining in human cerebellum using ab8957.
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![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulon 1A antibody [MON160] (ab8957)](https://www.abcam.com/ps/products/8/ab8957/Images/ab8957_2.gif)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Reticulon 1A antibody [MON160] (ab8957)Human carcinoid (A) and small cell lung carcinoma (B) in paraffin sections, immunostained for NSP-A with ab8957.
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![Schematic Diagram - Anti-Reticulon 1A antibody [MON160] (ab8957)](https://www.abcam.com/ps/products/8/ab8957/Images/ab8957_3.gif)
Schematic Diagram - Anti-Reticulon 1A antibody [MON160] (ab8957)Schematic representation of of the deduced domain structure of the three NSP-gene encoded proteins, NSP-A, NSP-B and NSP-C and mapping of the epitopes recognized by the different NSP monoclonal antibodies.
