Anti-Maxi Potassium channel beta/KCNMB1 antibody

Rabbit polyclonal to Maxi Potassium channel beta/KCNMB1

Rabbit

ab3587 is specific for the Beta-1 subunit of Maxi K+. It does not detect the beta-2 subunit

Reacts with: Mouse, Rat, Rabbit, Dog, Human, Pig
Predicted to work with: Cow

Synthetic peptide corresponding to Human Maxi Potassium channel beta/KCNMB1 aa 90-103.
Sequence:

LYHTEDTRDQNQQC

(Peptide available as ab5023)

Run BLAST with Run BLAST with

Liquid

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

Preservative: 0.05% Sodium azide
Constituents: 0.1% BSA, 99% PBS

Immunogen affinity purified

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Polyclonal

IgG

• Neuroscience
• Neurotransmission
• Receptors / Channels
• Potassium Channels

• Signal Transduction
• Metabolism
• Plasma Membrane
• Channels

• Cardiovascular
• Blood
• Blood Pressure regulation

• Cardiovascular
• Vasculature
• Vasoconstriction
• Other

• Cardiovascular
• Vasculature
• Vasodilation
• Other

• Metabolism
• Types of disease
• Cancer