Anti-ARHGEF9 antibody (ab87148)
Key features and details
- Rabbit polyclonal to ARHGEF9
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-ARHGEF9 antibody
See all ARHGEF9 primary antibodies -
Description
Rabbit polyclonal to ARHGEF9 -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species WB Human
-
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
-
Positive control
- This antibody gave a positive signal in human brain and heart tissues lysates.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration
Concentration information loading...Purity
Immunogen affinity purifiedClonality
PolyclonalIsotype
IgGResearch areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab87148 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
GuaranteedTested applications are guaranteed to work and covered by our Abpromise guarantee.
PredictedPredicted to work for this combination of applications and species but not guaranteed.
IncompatibleDoes not work for this combination of applications and species.
Application Species WB HumanAll applications MouseRatCowOrangutanApplication Abreviews Notes WB Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).Notes WB
Use a concentration of 1 µg/ml. Detects a band of approximately 61 kDa (predicted molecular weight: 61 kDa).Target
-
Function
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. -
Tissue specificity
Detected in brain. Detected at low levels in heart. -
Involvement in disease
Defects in ARHGEF9 are a cause of startle disease with epilepsy (STHEE) [MIM:300607]; also known as hyperekplexia with epilepsy. Startle disease is a genetically heterogeneous neurologic disorder. STHE is characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli. -
Sequence similarities
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 SH3 domain. -
Cellular localization
Cytoplasm. - Information by UniProt
-
Database links
- Entrez Gene: 537718 Cow
- Entrez Gene: 23229 Human
- Entrez Gene: 236915 Mouse
- Entrez Gene: 66013 Rat
- Omim: 300429 Human
- SwissProt: Q58DL7 Cow
- SwissProt: O43307 Human
- SwissProt: Q3UTH8 Mouse
see all -
Alternative names
- 9630036L12Rik antibody
- A230067K14 antibody
- ARHG9_HUMAN antibody
see all
Images
-
Western blot - Anti-ARHGEF9 antibody (ab87148)All lanes : Anti-ARHGEF9 antibody (ab87148) at 1 µg/ml
Lane 1 : Human brain tissue lysate - total protein (ab29466)
Lane 2 : Human heart tissue lysate - total protein (ab29431)
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size: 61 kDa
Observed band size: 61 kDa
Exposure time: 12 minutes
Datasheets and documents
References (0)
ab87148 has not yet been referenced specifically in any publications.
Images
-
Western blot - Anti-ARHGEF9 antibody (ab87148)All lanes : Anti-ARHGEF9 antibody (ab87148) at 1 µg/ml
Lane 1 : Human brain tissue lysate - total protein (ab29466)
Lane 2 : Human heart tissue lysate - total protein (ab29431)
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size: 61 kDa
Observed band size: 61 kDa
Exposure time: 12 minutes
