Anti-ALK-7 antibody (ab65088)
Key features and details
- Rabbit polyclonal to ALK-7
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ALK-7 antibody
See all ALK-7 primary antibodies -
Description
Rabbit polyclonal to ALK-7 -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species WB Human
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Immunogen
Synthetic peptide within Human ALK-7 aa 100-200 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
(Peptide available asab74349) -
Positive control
- This antibody gave a positive signal in Human spleen tissue lysate. It also gave positive results in Human lung, ovary, placenta, heart, testis and kidney (data not shown).
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General notes
Protein previously known as Activin A Receptor Type IC.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituent: PBS
Batches of this product that have a concentration
Concentration information loading...Purity
Immunogen affinity purifiedClonality
PolyclonalIsotype
IgGResearch areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab65088 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
GuaranteedTested applications are guaranteed to work and covered by our Abpromise guarantee.
PredictedPredicted to work for this combination of applications and species but not guaranteed.
IncompatibleDoes not work for this combination of applications and species.
Application Species WB HumanApplication Abreviews Notes WB Use a concentration of 2 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 55 kDa).Notes WB
Use a concentration of 2 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 55 kDa).Target
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Function
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. -
Tissue specificity
Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 130399 Human
- Omim: 608981 Human
- SwissProt: Q8NER5 Human
- Unigene: 562901 Human
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Alternative names
- Activin A receptor, type IC antibody
- Activin receptor like kinase 7 antibody
- Activin receptor type 1C precursor antibody
see all
Images
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Western blot - Anti-ALK-7 antibody (ab65088)Anti-ALK-7 antibody (ab65088) at 2 µg/ml + Human spleen tissue lysate - total protein (ab29699) at 20 µg
Secondary
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size: 55 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
Exposure time: 30 secondsThe 70 kDa band observed is comparable to the molecular weight seen with other commercially available antibodies to ALK-7.
Datasheets and documents
References (0)
ab65088 has not yet been referenced specifically in any publications.
Images
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Western blot - Anti-ALK-7 antibody (ab65088)Anti-ALK-7 antibody (ab65088) at 2 µg/ml + Human spleen tissue lysate - total protein (ab29699) at 20 µg
Secondary
Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
Performed under reducing conditions.
Predicted band size: 55 kDa
Observed band size: 70 kDa why is the actual band size different from the predicted?
Exposure time: 30 secondsThe 70 kDa band observed is comparable to the molecular weight seen with other commercially available antibodies to ALK-7.
