AMD 3465 hexahydrobromide, CXCR4 antagonist (ab120809)
Key features and details
- Potent and selective CXCR4 antagonist
- CAS Number: 185991-07-5
- Purity: > 97%
- Soluble in water to 50 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AMD 3465 hexahydrobromide, CXCR4 antagonist -
Description
Potent and selective CXCR4 antagonist -
Biological description
Potent and selective CXCR4 antagonist. Shows 8-fold greater affinity than AMD 3100 (ab120718). Potent HIV entry inhibitor (IC50 = ~10 nM). Additionally mobilizes stem cells in vivo.
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Purity
> 97% -
CAS Number
185991-07-5 -
Chemical structure
Properties
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Chemical name
N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide -
Molecular weight
896.08 -
Molecular formula
C24H38N6.6HBr -
PubChem identifier
483559 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM and in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Br.Br.Br.Br.Br.Br.C3NCCCNCCN(Cc2ccc(CNCc1ccccn1)cc2)CCCNC3 -
Source
Synthetic
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Research areas
