ALLM, calpain inhibitor (ab141446)
Key features and details
- Potent, cell-permeable calpain inhibitor. Highly potent cathepsin inhibitor.
- CAS Number: 136632-32-1
- Purity: > 95%
- Soluble in DMSO to 50 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ALLM, calpain inhibitor -
Description
Potent, cell-permeable calpain inhibitor. Highly potent cathepsin inhibitor. -
Biological description
Potent, cell-permeable calpain inhibitor (Ki values and 120 and 230 nM at calpain I and II respectively). Highly potent cathepsin inhibitor (Ki values are 0.6 and 100 nM at cathepsin L and B respectively). Promotes caspase-dependent apoptosis in cancer cells. Antitumor agent. Active in vivo and in vitro. -
Purity
> 95% -
CAS Number
136632-32-1 -
Chemical structure
Properties
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Molecular weight
401.57 -
Molecular formula
C19H35N3O4S -
Sequence
LLM (Modifications: N-terminal acetyl; C-terminal aldehyde) -
PubChem identifier
4331 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C -
Source
Synthetic
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Research areas
