AG-370, PDGFR tyrosine kinase inhibitor (ab141563)
Key features and details
- Selective PDGFR tyrosine kinase inhibitor
- CAS Number: 134036-53-6
- Purity: > 99%
- Soluble in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AG-370, PDGFR tyrosine kinase inhibitor -
Description
Selective PDGFR tyrosine kinase inhibitor -
Biological description
Selective platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 = 20 μM). Weak epidermal growth factor receptor (EGFR) inhibitor (IC50 = 820 μM). Blocks proliferative effect of PDGF. -
Purity
> 99% -
CAS Number
134036-53-6 -
Chemical structure
Properties
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Chemical name
(3Z)-2-Amino-4-(1H-indol-5-yl)buta-1,3-diene-1,1,3-tricarbonitrile -
Molecular weight
259.30 -
Molecular formula
C15H9N5 -
PubChem identifier
5328748 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=CN2)C=C1C=C(C#N)C(=C(C#N)C#N)N -
Source
Synthetic
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Research areas
