Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)
Key features and details
- Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor
- CAS Number: 439081-18-2
- Purity: > 98%
Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Powder
- Source: Synthetic
Overview
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Product name
Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor -
Description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor -
Biological description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
439081-18-2 -
Chemical structure
