AC187, amylin receptor antagonist (ab141150)
Key features and details
- Potent, selective amylin receptor antagonist
- CAS Number: 151804-77-2
- Purity: > 95%
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AC187, amylin receptor antagonist -
Description
Potent, selective amylin receptor antagonist -
Biological description
Potent, selective amylin receptor antagonist (IC50 = 0.48 nM). Displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity following reduced activation of caspases, XIAP and BID in vitro. Role in glucose homeostasis.
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Purity
> 95% -
CAS Number
151804-77-2 -
Chemical structure
Properties
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Molecular weight
2890.24 -
Molecular formula
C127H205N37O40 -
Sequence
VLGKLSQELHKLQTYPRTNTGSNTY (Modifications: N-terminal acetyl; C-terminal amide) -
PubChem identifier
16133792 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
