ABT-737, BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor (ab141336)
Key features and details
- BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor
- CAS Number: 852808-04-9
- Purity: > 95%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ABT-737, BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor -
Description
BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor -
Biological description
BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor. Triggers Bax/Bak-mediated apoptosis (EC50 values are 79, 30 and 198 nM for Bcl-xL, Bcl-2 and Bcl-w mediated apoptosis respectively). Shows antitumor effects in vivo. -
Purity
> 95% -
CAS Number
852808-04-9 -
Chemical structure
Properties
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Chemical name
4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide -
Molecular weight
813.45 -
Molecular formula
C42H45ClN6O5S2 -
PubChem identifier
11228183 -
Storage instructions
Store at +4°C. -
Handling
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SMILES
CN(C)CCC(CSc1ccccc1)Nc2ccc(cc2[N+](=O)[O-])S(=O)(=O)NC(=O)c3ccc(cc3)N4CCN(CC4)Cc5ccccc5c6ccc(cc6)Cl -
Source
Synthetic
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Research areas
