Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor
CAS Number: 852808-04-9
Purity: > 95%
Form / State: Solid
Source: Synthetic

Product name

ABT-737, BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor
Description

BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor
Biological description

BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor. Triggers Bax/Bak-mediated apoptosis (EC₅₀ values are 79, 30 and 198 nM for Bcl-xL, Bcl-2 and Bcl-w mediated apoptosis respectively). Shows antitumor effects in vivo.
Purity

> 95%
CAS Number

852808-04-9
Chemical structure

Chemical name

4-[4-[[2-(4-Chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide
Molecular weight

813.45
Molecular formula

C₄₂H₄₅ClN₆O₅S₂
PubChem identifier

11228183
Storage instructions

Store at +4°C.
Handling

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES

CN(C)CCC(CSc1ccccc1)Nc2ccc(cc2[N+](=O)[O-])S(=O)(=O)NC(=O)c3ccc(cc3)N4CCN(CC4)Cc5ccccc5c6ccc(cc6)Cl
Source

Synthetic
Research areas

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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ABT-737, BH3 mimetic Bcl-xL, Bcl-2 and Bcl-w inhibitor (ab141336)

Key features and details

Overview

Product name

Description

Biological description

Purity

CAS Number

Chemical structure

Properties

Chemical name

Molecular weight

Molecular formula

PubChem identifier

Storage instructions

Handling

SMILES

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