ABT-263, Bcl-2 family protein inhibitor (ab218114)
Key features and details
- Potent, small molecule Bcl-2 family protein inhibitor
- CAS Number: 923564-51-6
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
ABT-263, Bcl-2 family protein inhibitor -
Description
Potent, small molecule Bcl-2 family protein inhibitor -
Alternative names
- A-855071
- ABT263
- Navitoclax
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Biological description
Potent, small molecule Bcl-2 family protein inhibitor (Ki’s of L and Bcl-w). Orally bioavailable. Displays anticancer properties. Selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and disrupts Bcl-2/Bcl-XL interactions with pro-death proteins, leading to the initiation of apoptosis. Induces Bax translocation, cytochrome c release, and subsequent apoptosis.
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Purity
> 98% -
CAS Number
923564-51-6 -
Chemical structure
Properties
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Chemical name
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide -
Molecular weight
974.61 -
Molecular formula
C47H55ClF3N5O6S3 -
PubChem identifier
24978538 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)N[C@H](CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C -
Source
Synthetic
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Research areas
