A23187 (Calcimycin), Ca2+ ionophore (ab120287)
Key features and details
- Ca2+ ionophore
- CAS Number: 52665-69-7
- Purity: > 98%
- Soluble in DMSO to 100 mM (with heating)
- Form / State: Solid
- Source: Steptomyces chartreusensis
Overview
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Product name
A23187 (Calcimycin), Ca2+ ionophore -
Description
Ca2+ ionophore -
Alternative names
- calcimycin
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Biological description
A mobile ion-carrier that forms stable complexes with divalent cations. Useful for increasing intracellular Ca2+ levels. Also acts as an uncoupler of oxidative phosphorylation and inhibitor of mitochondrial ATPase activity. An antibiotic with weak activity against Gram-positive bacteria.
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Purity
> 98% -
CAS Number
52665-69-7 -
Chemical structure
Properties
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Chemical name
5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7- dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid -
Molecular weight
523.63 -
Molecular formula
C29H37N3O6 -
PubChem identifier
11957499 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)c1c(NC)ccc2oc(nc12)C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5cccn5 -
Source
Steptomyces chartreusensis
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Research areas
