A-412997 dihydrochloride, D4 agonist (ab120581)
Key features and details
- Highly selective D4 agonist
- CAS Number: 630116-49-3
- Purity: > 98%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
A-412997 dihydrochloride, D4 agonist -
Description
Highly selective D4 agonist -
Biological description
Highly selective dopamine D4 receptor agonist at rat D4 and human D4.4 receptors (Ki values are 12.1 and 7.9 nM, respectively). Potent, full agonist at rat dopamine D4 receptors (EC50 = 28.4 nM). Superior selectivity profile to PD168077 (ab120568) and CP226269. No affinity for other dopamine receptors (Ki > 1 μM). Able to rapidly cross the blood-brain barrier following systemic administration.
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Purity
> 98% -
CAS Number
630116-49-3 -
Chemical structure
Properties
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Chemical name
N-(3-Methylphenyl)-2-[4-(2-pyridinyl)-1-piperidinyl]acetamide dihydrochloride -
Molecular weight
382.33 -
Molecular formula
C19H23N3O.2HCl -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
