5,15-DPP (Stat3 Inhibitor VIII), STAT3 inhibitor (ab146023)
Key features and details
- Potent, selective, cell-permeable STAT3 inhibitor
- CAS Number: 22112-89-6
- Purity: > 98%
- Soluble in chloroform
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
5,15-DPP (Stat3 Inhibitor VIII), STAT3 inhibitor -
Description
Potent, selective, cell-permeable STAT3 inhibitor -
Biological description
Potent, selective, cell-permeable STAT3 inhibitor (Kd = 880 nM). Inhibits STAT3 dimerization (IC50 values are 0.28 and 10 μM for STAT3 SH2 domain-mediated ligand binding and STAT1 ligand binding, respectively). Blocks TRAIL-induced invasion.
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Purity
> 98% -
CAS Number
22112-89-6 -
Chemical structure
Properties
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Chemical name
5,15-Diphenyl-21H,23H-porphine -
Molecular weight
462.55 -
Molecular formula
C32H22N4 -
PubChem identifier
10895852 -
Storage instructions
Store at +4°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. -
Solubility overview
Soluble in chloroform -
Handling
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
n5c6cc1nc(C=C1)c(c2ccccc2)c7ccc(cc3C=Cc(n3)c(c4ccccc4)c5cc6)n7 -
Source
Synthetic
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Research areas
