Anti-FEM 1B antibody (ab3686)
Key features and details
- Rabbit polyclonal to FEM 1B
- Suitable for: WB, ICC/IF, IHC-P
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-FEM 1B antibody -
Description
Rabbit polyclonal to FEM 1B -
Host species
Rabbit -
Tested applications
Suitable for: WB, ICC/IF, IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat -
Immunogen
Synthetic peptide:
DINYQDQIPRTLEE
, corresponding to amino acids 609-622 of Human FEM 1B(Peptide available as ab6098.) -
General notes
Fas and Tumor Necrosis Factor Receptor 1 (TNFR 1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR 1 was recently identified and designated F1A alpha and FEM 1 beta. F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM 1. FEM 1/F1Aa is cleaved by CED-3 and caspase. FEM 1/F1Aa associates with CED-4 and its mammalian homologue Apaf 1. Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Primary antibody notes
Fas and Tumor Necrosis Factor Receptor 1 (TNFR 1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR 1 was recently identified and designated F1A alpha and FEM 1 beta. F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM 1. FEM 1/F1Aa is cleaved by CED-3 and caspase. FEM 1/F1Aa associates with CED-4 and its mammalian homologue Apaf 1. Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Images
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Western blot analysis of F1A alpha in mouse (A) and rat (B) liver tissue lysates with anti-F1A alpha (ab3686) at 1
Western blot analysis of FEM 1B in mouse (A) and rat (B) liver tissue lysates with anti-FEM 1B (ab3686) at 1 µg /ml.µ g /ml. -
Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse liver tissue labeling FEM 1B with Anti-FEM 1B antibody (ab3686) at 20μg/ml.
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ab3686 at 5µg/ml staining of FEM 1B in mouse liver tissue by IHC
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Immunofluorescence of F1A alpha in Mouse Liver cells using ab3686 at 20 ug/ml.